Perineural Injection Treatment

What is the Science Underlying this Therapy?

Joint replacement, Platelet Injections, and stem cell therapy are not suitable for everyone with chronic pain. Trauma, arthritis, sports injuries, overuse, occupational or surgical injuries are all prevalent causes of nerve injury. PIT, or Perineural Injection Therapy, may help these patients.

The research is based on a better knowledge of nerve pain signaling. A peripheral nerve is stimulated by pain. The nerve subsequently transmits an electrical current to the brain and spinal cord. A flow of molecules with positive or negative charges into and out of the cell via a receptor — a door-like structure in the cell wall – generates the current. This ion flow is disrupted by injury.

The nerve then sends pain signals to the brain, including nerve growth factor and substance P. Long after the pain stimulus has passed, these pain molecules continue to be released. Local tissue including muscle, tendon, and ligaments are also prevented from healing by these pain compounds. Neurogenic pain is another term for it.

How Can the Nerve Become Inflamed?

Inflammation of the nerves can occur in numerous ways:

  • When a nerve is constricted or compressed as it passes through a tunnel in a bone, it can become inflamed.
  • As a nerve passes back and forth over the surface of a bone, friction can cause inflammation. This is common among runners and cyclists.
  • Scar tissue that entangles or constricts nerves can result from overuse.
    When nerves run through fascia, they might become inflamed. Trigger points can be found in these regions.

What is the method of treatment?

During the procedure, a mild Dextrose solution is employed.

Dextrose is hypothesized to enter the nerve cell through the receptor, restoring normal function and helping to reset and restore neuron function.

Subcutaneous (under the skin) injections with a small needle are used for treatment. The majority of individuals require 4-8 PITs spaced 1 to 4 weeks apart.

The number of injections required is determined by the number of affected nerves, the length of time they have been inflamed, and the extent of the nerve inflammation.


Each treatment can help to reduce pain gradually. All pain will be relieved, and function will improve.

According to Dr. John Lyftogt’s research, PIT can help up to 85% of patients. Because opioids compete with dextrose at the receptor site, users do not respond well.

Are there any restrictions on activities?

On the day of the operation, patients should rest.

Minor bruising is one of the few side effects. Infection can happen with any injection, although PIT is unusual. There has been no mention of allergies.

What Conditions Can PIT Help Treat?

Neck pain
Occipital myalgia
Tension Headaches
Migraine headaches
Thoracic pain
Lower back pain
Shoulder pain
Knee pain
Hand osteoarthritis
Morton’s neuroma

Where can I Find a Practitioner who Does this Procedure?

The physicians at Nova Integrated Health have extensive experience performing Perineural Injection treatments for many years.

Call us today at Nova Integrated Health to schedule an appointment and see if PIT is an option for you!


Stiene, H. (2019). Perineural injection therapy (PIT or Lyftogt Technique). Retrieved Feb 27, 2019 from >

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